Courses and programs being delivered at a distance require a unique set of professional competencies. Whether using synchronous or asynchronous methods of instruction, systematic instructional design can help stimulate motivation, increase interaction and social presence, and authenticate learning outcomes. Principles of adult learning, including self-directed and student-centered learning approaches are emphasized in this Advanced Methods in Distance Education: Applications and Practices for Educators, Administrators and Learners. It is designed to be theory to practice, with readers gaining the necessary knowledge, skills, and abilities to be successful in teaching or training using technology-mediated instruction. Major sections include: Foundations of Teaching and Learning at a Distance, Adult Learning, Instructional Design, Technology Knowledge and Skills, Administrative Issues, and Future Directions.